Low testosterone is a common condition that affects many men, leading to a range of symptoms such as low sex drive, fatigue, and reduced muscle mass. To tackle this issue, various treatment options are available, including medications like Enclomiphene and Clomiphene. In this blog post, we will explore the distinctions between these two medications and shed light on their effectiveness in the management of low testosterone.

The Basics of Low Testosterone

Before delving into the differences between Enclomiphene and Clomiphene, it’s important to understand the basics of low testosterone. Testosterone is a hormone that plays a crucial role in masculine development and overall health. As men age, the production of testosterone naturally declines, often resulting in bothersome symptoms. Low testosterone can affect men of any age, but it is more prevalent in older individuals.

You can take our Low T quiz here to see if you are at high risk for low testosterone.

What is Enclomiphene?

Enclomiphene is a selective estrogen receptor modulator (SERM). While enclomiphene is not individually approved by the FDA, it is a key ingredient in Clomid, an FDA-sanctioned fertility medication widely used by women and often prescribed off-label for men with low testosterone levels. Consequently, as long as there are no updates to the FDA’s list, pharmacies are permitted to compound and provide enclomiphene based on a doctor’s prescription. This medication works by stimulating the production of testosterone in the testes, helping to restore hormonal balance. Enclomiphene helps increase the levels of follicle-stimulating hormone (FSH), which in turn promotes the production of testosterone.

Testosterone Therapy

Understanding Clomiphene

Clomiphene is also a SERM that has been widely used for the treatment of female infertility. However, it can also be used off-label to boost testosterone levels in men with low testosterone. Similar to Enclomiphene, Clomiphene stimulates the production of FSH, resulting in increased testosterone production. It is worth noting that Clomiphene consists of a 50:50 mixture of two isomers – Enclomiphene and Zuclomiphene.

Key Distinctions between Enclomiphene and Clomiphene

The primary distinction between Enclomiphene and Clomiphene lies in their isomeric composition. Enclomiphene, being one of the two isomers present in Clomiphene, is believed to be responsible for the therapeutic effects of the medication. On the other hand, Zuclomiphene has been associated with a higher risk of estrogenic side effects. Therefore, Enclomiphene, being free of the potentially problematic isomer, is considered a more favorable option.

Effectiveness in Treating Low Testosterone

Both Enclomiphene and Clomiphene have shown promise in increasing testosterone levels in men with low testosterone. Studies have demonstrated that Enclomiphene significantly improves serum testosterone levels while maintaining fertility hormone balance. Additionally, Enclomiphene has shown to have a better safety profile than Clomiphene, with fewer incidences of adverse side effects.

Potential Side Effects

While Enclomiphene and Clomiphene are generally considered safe, it is important to be aware of potential side effects. Common side effects may include hot flashes, mood swings, and headaches. However, these side effects are often temporary and subside with continued usage. It is always recommended to consult with a healthcare professional before starting any medication.


In conclusion, Enclomiphene and Clomiphene are two medications commonly used for the treatment of low testosterone in men. While they share similarities in their mechanism of action, the key distinction is in their isomeric composition. Enclomiphene, free of the potentially problematic isomer, offers a more favorable and effective treatment option. Nonetheless, it is crucial to consult with a medical professional to determine the most suitable approach for managing low testosterone, as individual circumstances may vary.

Remember, understanding the distinctions between Enclomiphene and Clomiphene is essential in making an informed decision about the best course of treatment for low testosterone. By seeking medical advice and considering individual needs, men can take positive steps towards regaining hormonal balance and improving their overall quality of life. Want to see what treatment is best for you? Contact us for a free consultation

Erez Cohen

Erez Cohen is a men's health specialist with over 15 years of experience in the men's health space. After being born in Israel, Erez moved to the United States worked for a number of Men's Health clinics before opening up Florida Men's Health Center in 2010 with the goal of helping men with a wide array of issues.